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Isis expects to earn initial payments of nearly $4 million from Alnylam's recent RNAi collaboration

Isis Pharmaceuticals, Inc. (Carlsbad, CA) expects to receive initial payments of nearly $4 million from Alnylam as a result of Alnylam's recently announced alliance with a major pharmaceutical company for the development of RNA interference (RNAi) therapeutics. Isis is entitled to a portion of the upfront payments and equity investment under Alnylam's recent collaboration. In addition, Isis has the potential to earn additional revenue in the form of milestone and royalty payments on drugs which utilize the Isis technology licensed to Alnylam. Alnylam's recent collaboration is subject to customary regulatory approvals, including antitrust review under the Hart-Scott-Rodino Antitrust Improvements Act.

"As a leader in RNA-based drug discovery and development, we have built one of the industry's largest patent estates focused on RNA. Leveraging our intellectual property position through licensing agreements, such as the agreement with Alnylam, allows us to realize significant value from our inventions in oligonucleotide chemistry and antisense mechanisms, including RNAi," said B. Lynne Parshall, Executive Vice President and Chief Financial Officer of Isis Pharmaceuticals.

"When we forged the alliance with Alnylam in 2004, we did so believing they were the leaders in RNAi and had the ability to advance the potential of RNAi for therapeutic applications. Our strategy at Isis is to actively create opportunities for the industry to access our patents, allowing us to generate revenue for the continued development of our drugs, while supporting our partners' efforts for the advancement of new drugs capable of treating a broad range of disease. Alnylam's recently announced major alliance is an example of this strategy at work, as it allows us to participate in all areas of RNA-based drug discovery, including RNAi," Ms. Parshall said.

In March 2004, Isis and Alnylam established an alliance that combines Isis' intellectual property and development expertise with Alnylam's intellectual property and research expertise in RNAi therapeutics. The patents Isis licensed to Alnylam include the "Crooke" patents that describe fundamental mechanisms for RNase-dependent antisense activity and chemically modified oligonucleotides designed to exploit such mechanisms. The license also includes over 150 issued United States patents from Isis' extensive portfolio of chemistry patents for use in modifying double-stranded oligonucleotides. As part of the agreement, Isis licensed to Alnylam its patent estate relating to certain antisense mechanisms and oligonucleotide chemistries for double-stranded RNAi therapeutics in exchange for a technology access fee, participation in fees for Alnylam's partnering programs, as well as downstream milestone and royalty payments.

Isis has an extensive intellectual property estate of more than 1,500 issued patents that the company owns or exclusively licenses covering RNA-based drug discovery. Isis' patent estate covers fundamental oligonucleotide chemistries; antisense drug discovery (multiple mechanisms); antisense therapeutics; manufacturing; formulations, and delivery of oligonucleotide therapeutics, as well as Ibis' RNA technology for the identification of infectious organisms.

RNA interference, or RNAi, is a naturally occurring mechanism within cells for selectively silencing and regulating specific genes. Since many diseases are caused by the inappropriate activity of specific genes, the ability to silence genes selectively through RNAi could provide a new way to treat a wide range of human diseases. RNAi is induced by small, double-stranded RNA molecules. One method to activate RNAi is with chemically synthesized small interfering RNAs, or siRNAs, which are doubled-stranded RNAs that correspond to a specific disease-associated gene. The siRNA molecules are used by the natural RNAi machinery in cells to cause highly targeted gene silencing. About Antisense

An antisense oligonucleotide hybridizes with a complementary target RNA to form a duplex. The formation of this duplex prevents the target RNA from functioning normally. Antisense drugs are short, chemically-modified RNA-like and DNA-like molecules that scientists design to complement a small, specific segment of messenger RNA. To date, there are at least 12 known antisense mechanisms, including RNase H, RNAi and alternative splicing. Each of these mechanisms has expanded the opportunities in which antisense drugs may be successful.

Isis is exploiting its expertise in RNA to discover and develop novel drugs for its product pipeline and for its partners. The company has successfully commercialized the world's first antisense drug and has 12 antisense drugs in development to treat metabolic, cardiovascular and inflammatory diseases, and cancer. In its Ibis division, Isis is developing and commercializing the TIGER biosensor system, a revolutionary system to identify infectious organisms. As an innovator in RNA-based drug discovery and development, Isis is the owner or exclusive licensee of more than 1,500 issued patents worldwide.

Isis Pharmaceuticals, Inc.
+1-760-603-2331
www.isispharm.com